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Related Experiment Videos

Urethral pressure changes in reflex micturition.

I M Khalaf, A Toppercer, M M Elhilali

    Investigative Urology
    |September 1, 1979
    PubMed
    Summary
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    Urethral pressure changes during bladder filling and voiding involve both muscle continuity and autonomic reflexes. These mechanisms are crucial for passive collection and active expulsion phases of bladder activity.

    Area of Science:

    • Urology
    • Physiology

    Background:

    • Urethral pressure is critical for urinary continence.
    • Understanding the mechanisms behind urethral pressure dynamics during bladder function is essential.

    Purpose of the Study:

    • To investigate the mechanisms and patterns of urethral pressure changes during bladder filling and voiding.
    • To differentiate the roles of vesicourethral muscle continuity and autonomic reflexes.

    Main Methods:

    • Simultaneous recording of intraurethral and intravesical pressures in anesthetized female dogs.
    • Experiments involved surgical separation of the bladder from the urethra.
    • Pharmacologic blockade of striated muscles, alpha-adrenergic receptors, and autonomic ganglia.

    Main Results:

    Related Experiment Videos

    • Urethral pressure rise during collection and drop during bladder contraction were observed.
    • Tubocurarine and phentolamine did not block key pressure changes.
    • Autonomic blockade prevented reflex micturition, but bethanechol chloride still induced bladder pressure rise and urethral pressure drop.

    Conclusions:

    • Both vesicourethral muscle continuity and autonomic reflexes contribute to urethral pressure changes.
    • These factors are vital for both passive urine collection and active voiding phases.