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Related Experiment Videos

Prolactin in human cerebrospinal fluid.

J Assies, A P Schellekens, J L Touber

    The Journal of Clinical Endocrinology and Metabolism
    |April 1, 1978
    PubMed
    Summary
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    Prolactin (PRL) is a normal component of cerebrospinal fluid (CSF) and its levels correlate with plasma concentrations. However, high CSF PRL levels alone do not indicate a pituitary tumor, especially with suprasellar extension (SSE).

    Area of Science:

    • Neuroendocrinology
    • Clinical Chemistry
    • Biochemistry

    Background:

    • Prolactin (PRL) is a hormone with various physiological roles.
    • Measuring PRL in both plasma and cerebrospinal fluid (CSF) can provide insights into its regulation and potential pathological conditions.
    • Pituitary tumors, particularly those with suprasellar extension (SSE), can affect PRL levels.

    Purpose of the Study:

    • To investigate the relationship between plasma and CSF PRL levels in different patient groups.
    • To determine the diagnostic value of CSF PRL levels in the presence of pituitary tumors.
    • To assess the utility of the plasma to CSF PRL ratio in differentiating conditions.

    Main Methods:

    • Radioimmunoassay was used to measure PRL concentrations in simultaneous plasma and CSF samples.

    Related Experiment Videos

  • Patients were categorized into groups based on neurological/infectious diseases, physiological hyperprolactinemia, pharmacologically induced hyperprolactinemia, and pituitary adenomas with/without SSE.
  • Statistical analysis, including correlation and ratio calculations, was performed.

    • Main Results:

    • PRL is a normal constituent of CSF, and CSF PRL levels are directly related to plasma PRL levels.
    • A positive correlation between plasma and CSF PRL was observed in both non-tumor and tumor patient groups.
    • The plasma to CSF PRL ratio was significantly lower in patients with pituitary tumors, especially those with SSE.

    Conclusions:

    • CSF PRL levels are a function of plasma PRL levels.
    • Elevated CSF PRL levels alone are not indicative of a pituitary tumor.
    • An abnormally low plasma to CSF PRL ratio may suggest the presence of a pituitary tumor with SSE.