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Anterior uveitis in ankylosing spondylitis: a histocompatibility study
Annals of Ophthalmology
|July 1, 1979
Summary
Ankylosing spondylitis patients positive for HLA-B 27 showed a higher incidence of acute anterior uveitis. This suggests uveitis and ankylosing spondylitis are distinct conditions strongly linked to the HLA-B 27 gene.
Area of Science:
- Immunogenetics
- Ophthalmology
- Rheumatology
Background:
- Ankylosing spondylitis is a chronic inflammatory disease primarily affecting the spine.
- Acute anterior uveitis is a common extra-articular manifestation of ankylosing spondylitis.
- The human leukocyte antigen HLA-B 27 is strongly associated with ankylosing spondylitis.
Purpose of the Study:
- To investigate the association between HLA-B 27 and acute anterior uveitis in patients with ankylosing spondylitis.
- To determine if acute anterior uveitis occurs independently of ankylosing spondylitis in the presence of HLA-B 27.
Main Methods:
- A comparative study involving 53 HLA-B 27 positive and 12 HLA-B 27 negative patients diagnosed with ankylosing spondylitis.
- Clinical assessment for the presence of acute anterior uveitis in all study participants.
Main Results:
- Acute anterior uveitis was exclusively observed in patients who were positive for HLA-B 27.
- No cases of acute anterior uveitis were detected in the HLA-B 27 negative ankylosing spondylitis patient group.
Conclusions:
- The findings strongly support a significant association between HLA-B 27 and the development of acute anterior uveitis in ankylosing spondylitis.
- Acute anterior uveitis and ankylosing spondylitis appear to be distinct but related conditions, both significantly linked to the HLA-B 27 genetic marker.