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Single case study. Amoxapine, a new antidepressant, appears in human milk
The Journal of Nervous and Mental Disease
|October 1, 1979
Summary
A young woman experienced galactorrhea while taking the antidepressant amoxapine. Both amoxapine and its metabolite were detected in breast milk, suggesting other antidepressants may also transfer to milk.
Area of Science:
- Pharmacology
- Endocrinology
- Neonatal Medicine
Background:
- Antidepressant use during lactation is a clinical concern.
- Understanding drug transfer into breast milk is crucial for infant safety.
- Dibenzoxazepine antidepressants represent a class requiring specific investigation.
Observation:
- A case study involving a young woman treated with amoxapine.
- Monitoring for adverse effects, including galactorrhea.
- Analysis of breast milk composition during amoxapine treatment.
Findings:
- Amoxapine, a dibenzoxazepine antidepressant, was associated with galactorrhea.
- Both amoxapine and its primary metabolite, 8-OH-amoxapine, were present in breast milk.
- This case highlights potential drug transfer of antidepressants into human milk.
Implications:
- Clinicians should be aware of the potential for amoxapine to induce galactorrhea and transfer into breast milk.
- The findings support the broader concern that most antidepressants may be excreted in human milk.
- Further research is needed to assess the safety and efficacy of antidepressant use during lactation.