[Effect of BCNU on the kinetics of the primary immune response in mice]

It was shown in experiments on mice administered the alkylating agent BCNU (1,3-bis/2-chlorethyl/-I-nitrosourea) at a dose of 20 mg/kg 48 or 72 hours following immunization wtih sheep red cells that kinetics of producing antibody-forming cells assumes a wave-like pattern with a sharp alternation of rises and falls in the number of antibody inducers. Analysis of the data obtained allowed a conclusion that BCNU does not affect the recruitment -- transformation of the precursor cells to antibody-forming cells.