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Related Experiment Videos

H-Y antigen in the teleost.

P Pechan, S S Wachtel, R Reinboth

    Differentiation; Research in Biological Diversity
    |January 1, 1979
    PubMed
    Summary

    The H-Y antigen, linked to mammalian sex determination, was found in three fish species. Its presence in YY males of Xiphophorus maculatus suggests a Y-chromosome role in teleost H-Y antigen expression.

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    Area of Science:

    • Comparative immunology
    • Evolutionary genetics
    • Reproductive biology

    Background:

    • The H-Y antigen is a cell surface antigen crucial for mammalian male sex determination.
    • Its presence is typically associated with the Y-chromosome and male heterogamety.
    • Understanding H-Y antigen conservation and function in non-mammalian vertebrates can illuminate sex determination mechanisms.

    Purpose of the Study:

    • To investigate the presence and potential role of H-Y antigen in teleost fish.
    • To explore the association of H-Y antigen with sex chromosomes in fish.
    • To assess the evolutionary conservation of H-Y antigen and its link to gonad differentiation.

    Main Methods:

    • Serological detection of H-Y antigen in three teleost fish species: Xiphophorus maculatus, Haplochromis burtoni, and Oryzias latipes.
    • Analysis of H-Y antigen presence in males and females, including specific genotypes like YY males in X. maculatus.
    • Examination of H-Y antigen in hybrids of the genus Tilapia.

    Main Results:

    • H-Y antigen was detected in males of all three studied teleost species and in Tilapia hybrids.
    • In Xiphophorus maculatus, H-Y antigen was most readily detected in YY males, indicating a potential Y-chromosome determinant.
    • While H-Y antigen was consistently found in males, male heterogamety was not definitively established for H. burtoni.

    Conclusions:

    • The H-Y antigen is conserved across a wide phylogenetic range, extending to teleost fish.
    • Evidence suggests a Y-chromosome linkage for H-Y antigen expression in X. maculatus, but its universal association with male heterogamety in teleosts requires further investigation.
    • The precise role of serologically defined H-Y antigen in teleost gonad differentiation remains an open question.

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