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Related Experiment Videos

Chorea induced by oral contraceptives.

P A Nausieda, W C Koller, W J Weiner

    Neurology
    |December 1, 1979
    PubMed
    Summary

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    Oral contraceptives can rarely cause chorea, a movement disorder. This condition reversed in young women after stopping the medication, suggesting a link to dopaminergic activity.

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Oral contraceptive therapy is widely used for birth control.
    • Chorea is a rare but recognized complication associated with oral contraceptives.

    Observation:

    • Five cases of chorea are presented in young, nulliparous women (average age 19) shortly after initiating oral contraceptives.
    • Patients had varying medical histories, including prior Sydenham chorea, Henoch-Schönlein purpura, and congenital cyanotic heart disease.

    Findings:

    • Chorea symptoms developed within an average of 5 weeks of starting oral contraceptives.
    • All patients experienced resolution of dyskinesia upon discontinuation of the contraceptive medication.
    • Preexisting striatal abnormalities may increase susceptibility to oral contraceptive-induced chorea.
    Keywords:
    Acceptor CharacteristicsBiologyCase StudiesCentral Nervous SystemCentral Nervous System EffectsChoreaContraceptionContraceptive Agents, Estrogen--administraction and dosageContraceptive Agents, Female--administraction and dosageContraceptive Agents--administraction and dosageContraceptive Methods--side effectsDiseasesFamily PlanningOral Contraceptives--side effectsPhysiologyResearch MethodologySigns And SymptomsStudies

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    Implications:

    • Oral contraceptive-induced chorea is a reversible condition.
    • Altered central dopaminergic activity is a potential mechanism underlying this complication.
    • Further research is needed to elucidate the exact mechanism and identify at-risk individuals.