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Reduced myocardial ATP and creatine phosphate in diabetes: role of 2,3-diphosphoglycerate
Recent Advances in Studies on Cardiac Structure and Metabolism
|January 1, 1975
Abstract:
Observations are presented which suggest that myocardial cellular hypoxia may account for the reduction in myocardial ATP and CP in the ketoacidotic diabetic state. It is suggested that reduced 2,3-diphosphoglycerate adversely affects oxygen release from the red blood cell, thereby leading to myocardial cellular hypoxia.