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[The efficacy of pleuromutilins on Aegyptianella pullorum infections in chickens (author's transl)]
Tropenmedizin Und Parasitologie
|September 1, 1979
Abstract:
Pleuromutilins have an aegyptianellicidal efficacy. A significant chemotherapeutic influence on the course of the infection in chickens could only be achieved after repeated oral and intramuscular applications of at least 150 mg and 75 mg/kg body weight respectively. However, even at these concentrations the infections were not cleared.
Insights
Pleuromutilins show efficacy against Aegyptianella infections in chickens. However, repeated high doses were needed for a significant chemotherapeutic effect, and infections were not fully cleared.
Area of Science:
- Veterinary Medicine
- Parasitology
- Pharmacology
Background:
- Aegyptianella infections pose a significant threat to poultry health.
- Pleuromutilins are a class of antibiotics with potential antimicrobial activity.
Purpose of the Study:
- To evaluate the aegyptianellicidal efficacy of pleuromutilins in chickens.
- To determine effective dosages and administration routes for pleuromutilin treatment.
Main Methods:
- Chickens infected with Aegyptianella were treated with pleuromutilins via oral and intramuscular routes.
- Various dosages were administered repeatedly to assess therapeutic influence.
Main Results:
- Pleuromutilins demonstrated aegyptianellicidal efficacy.
- Significant chemotherapeutic effects required repeated high doses (150 mg/kg oral, 75 mg/kg intramuscular).
- Complete clearance of infection was not achieved even at tested concentrations.
Conclusions:
- Pleuromutilins exhibit therapeutic potential against Aegyptianella infections in chickens.
- Optimized dosing and administration strategies are necessary for improved outcomes.
- Further research is warranted to achieve complete eradication of the parasite.