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Related Experiment Videos

Long spacing collagen in dermal disorders.

J Daróczy, M D Haust

    Acta Morphologica Academiae Scientiarum Hungaricae
    |January 1, 1979
    PubMed
    Summary

    Electron microscopy revealed long spacing collagen (LSC) in various skin conditions, including condyloma latum. LSC formation is linked to increased ground substance and extracellular microfibrils, not specific to one disorder.

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    Area of Science:

    • Dermatopathology
    • Connective Tissue Biology
    • Electron Microscopy

    Background:

    • Long spacing collagen (LSC) is an ultrastructural finding in connective tissues.
    • Its presence has been associated with various pathological conditions.
    • The specific role and formation mechanism of LSC remain areas of investigation.

    Purpose of the Study:

    • To investigate the presence and characteristics of LSC in specific dermatological conditions.
    • To explore the association between LSC and extracellular matrix components.
    • To determine if LSC is specific to any particular disorder.

    Main Methods:

    • Electron microscopic examination of biopsy specimens from patients with lichen sclerosus et atrophicus, condyloma latum, scleromyxoedema, and macular amyloidosis.
    • Analysis of collagen structures, ground substance, and extracellular microfibrils.

    Main Results:

    • Long spacing collagen (LSC) was identified in patients with lichen sclerosus et atrophicus, condyloma latum, scleromyxoedema, and macular amyloidosis.
    • The presence of LSC in condyloma latum is reported for the first time.
    • LSC displayed axial periodicity ranging from 1000 to 2000 Å and was intermingled with increased ground substance and extracellular microfibrils.

    Conclusions:

    • The appearance of LSC is not specific to any single disorder.
    • LSC formation is associated with increased glycosaminoglycan-rich ground substance.
    • Abundance of extracellular microfilaments in the extracellular space may contribute to LSC formation.

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