Monitoring cerebral blood flow during intracranial operations: an intravenous injection method

A method of measuring cerebral blood flow during neurosurgery is described. It is an adaptation of the standard 133Xe intravenous injection method, with computation restricted to data collected over the first 3 min. In addition to a theoretical presentation of the method and an analysis of the effect of residual 133Xe activity when sequential runs are performed in close approximation, the technique is validated experimentally by comparison with intracarotid 133Xe injection in baboons.