Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measles immunization. Successes and failures.

A S Yeager, J H Davis, L A Ross

    JAMA
    |January 24, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Incidence of spine surgery in the South African private healthcare sector: ten-year trends within a large open medical scheme.

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2023
    Same author

    Loss to follow-up among patients diagnosed with spinal tuberculosis at a tertiary hospital in Western Cape Province, South Africa: A retrospective cohort study.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2020
    Same author

    Child and adult spinal tuberculosis at tertiary hospitals in the Western Cape, South Africa: 4-year burden and trend.

    Epidemiology and infection·2018
    Same author

    Adding glucose to food and solutions to enhance fructose absorption is not effective in preventing fructose-induced functional gastrointestinal symptoms: randomised controlled trials in patients with fructose malabsorption.

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2016
    Same author

    Aggregation pheromone for the pepper weevil,Anthonomus eugenii cano (Coleoptera: Curculionidae): Identification and field activity.

    Journal of chemical ecology·2013
    Same author

    Ceftriaxone pharmacokinetic properties during continuous veno-veno haemofiltration using an in vitro adult, paediatric and neonatal model.

    Perfusion·2013
    Same journal

    Deaths Caused by Law Enforcement in the US.

    JAMA·2026
    Same journal

    Hepatitis B.

    JAMA·2026
    Same journal

    Lung Transplant for Refractory Lung-Limited Stage IV Non-Small Cell Lung Cancer.

    JAMA·2026
    Same journal

    AI vs Poetry in Medicine.

    JAMA·2026
    Same journal

    Rates of Precipitated Withdrawal in a Trial of ED-Initiated Buprenorphine for Opioid Use Disorder-Reply.

    JAMA·2026
    Same journal

    New Lungs for Lung Cancer-Perils and Promises.

    JAMA·2026
    See all related articles

    Children immunized against measles before 13 months of age had lower antibody titers, suggesting vaccine failure. Reimmunization programs are recommended for this group to improve measles immunity.

    Area of Science:

    • Immunology
    • Pediatrics
    • Public Health

    Background:

    • Measles outbreaks necessitate evaluating vaccine effectiveness.
    • Hemagglutination inhibition (HI) titers are a key measure of measles immunity.

    Purpose of the Study:

    • To assess measles antibody titers in immunized children during a large outbreak.
    • To determine the impact of immunization age on measles immunity levels.

    Main Methods:

    • Measles hemagglutination inhibition (HI) titers were measured in 465 immunized children.
    • Analysis compared antibody titers based on age at immunization.

    Main Results:

    • 14.6% of children immunized at 12 months had low titers (<1:4) versus 5.2% immunized at 13+ months.

    Related Experiment Videos

  • Children immunized earlier had lower titers, suggesting primary vaccine failure.
  • Maternal antibody levels were higher in seronegative children immunized at 11-12 months.

    • Conclusions:

    • Vaccine failure, not waning immunity, is the likely cause of low measles titers in some immunized children.
    • Immunization at 13 months or later is associated with higher protective antibody levels.
    • Reimmunization programs should target children vaccinated before 13 months of age.