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Related Experiment Videos

Pituitary adenoma calcification.

A M Landolt, V Rothenbühler

    Archives of Pathology & Laboratory Medicine
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Pituitary adenomas show calcifications in 6.6% of cases. Electron microscopy is the most effective method for detecting these calcifications, revealing hydroxyapatite crystal deposits in necrotic cells.

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    Area of Science:

    • Endocrinology
    • Pathology
    • Radiology

    Background:

    • Pituitary adenomas are common tumors, and calcifications within them are infrequently reported.
    • Understanding the characteristics and detection methods of pituitary adenoma calcifications is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of calcifications in pituitary adenomas.
    • To compare the efficacy of different detection methods for pituitary adenoma calcifications.

    Main Methods:

    • Examination of 137 pituitary adenomas using skull roentgenograms, light microscopy, and electron microscopy.
    • Ultrastructural analysis to characterize the nature of calcifications.
    • Correlation of calcifications with hormone secretion, including prolactin.

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    Main Results:

    • Calcifications were identified in 9 out of 137 pituitary adenomas (6.6%).
    • Electron microscopy was the most sensitive method, detecting calcifications in seven cases, compared to four with skull X-rays and two with light microscopy.
    • Calcifications originated from single necrotic cells undergoing fibrillary transformation, forming dense hydroxyapatite crystals.

    Conclusions:

    • Electron microscopy is superior for detecting calcifications in pituitary adenomas.
    • The calcification process appears distinct from typical dystrophic calcification.
    • Local factors and hormone secretion type may influence calcification patterns in pituitary adenomas.