Related Experiment Video

Updated: Feb 20, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

1.2K

Michaëlis--Menten kinetics of phenazone elimination in the perfused pig liver

B Andreasen, K Tonnesen, A Rabol

    Acta Pharmacologica Et Toxicologica
    |January 1, 1977
    PubMed

    More Related Videos

    Author Spotlight: Investigating Hepatic Adaptations and Prediabetic Progression in Liver Diseases06:21

    Author Spotlight: Investigating Hepatic Adaptations and Prediabetic Progression in Liver Diseases

    Published on: October 6, 2023

    2.7K
    Porcine Normothermic Isolated Liver Perfusion07:32

    Porcine Normothermic Isolated Liver Perfusion

    Published on: June 9, 2023

    1.5K

    Related Concept Videos

    Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

    Nonlinear Pharmacokinetics: Michaelis-Menten Equation

    The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
    Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
    1.1K
    Determination of Michaelis Constant and Maximum Elimination Rate01:20

    Determination of Michaelis Constant and Maximum Elimination Rate

    The Michaelis constant (KM) and the theoretical maximum process rate (Vmax) are vital parameters in the Michaelis-Menten equation, central to many biochemical reactions. They provide essential insights into enzyme kinetics and drug metabolism.
    These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
    514
    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

    Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
    A recent model describes pravastatin's hepatobiliary excretion,...
    331
    Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

    Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

    The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
    A study on guinea pigs examined the...
    725
    Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

    Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

    Drug administration can occur through various routes, each of which may result in a different process of elimination. This process is often mixed with nonlinear and linear processes. It's important to understand that a single drug can be metabolized into different metabolites through parallel processes.
    For instance, consider the metabolism of sodium salicylate. This compound is metabolized into two distinct substances: a glucuronide and a glycine conjugate. The rate of conjugation depends...
    390
    Kinetics of Drug Elimination01:17

    Kinetics of Drug Elimination

    Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
    Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
    4.3K