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Related Experiment Videos

Ferritin phagocytosis.

P Fishman, E Skutelski, M Djaldetti

    Archives of Pathology & Laboratory Medicine
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Normal and hypereosinophilic syndrome eosinophils exhibit similar in vitro phagocytosis of ferritin. Ferritin is found in vacuoles, not specific granules, in both cell types.

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    In Reply.

    Archives of pathology & laboratory medicine·2026
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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Eosinophils play a role in immune responses.
    • Hypereosinophilic syndrome (HES) involves elevated eosinophil counts.
    • The phagocytic capacity of HES eosinophils is not fully understood.

    Purpose of the Study:

    • To investigate the in vitro phagocytosis of ferritin by normal and HES eosinophils.
    • To compare the uptake of ferritin and cationized ferritin.
    • To examine the localization of ferritin within eosinophils.

    Main Methods:

    • In vitro incubation of normal and HES eosinophils with ferritin and cationized ferritin.
    • Light microscopy to observe cellular changes and vacuole formation.
    • Analysis of ferritin localization within cellular compartments.

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    Main Results:

    • Pseudopod formation observed within one minute of incubation.
    • Ferritin-containing vacuoles appeared after five minutes in both normal and HES eosinophils.
    • Ferritin was localized to membrane-bound vacuoles, not specific granules, up to 90 minutes.
    • No significant difference in phagocytic activity was found between normal and HES eosinophils or between ferritin types.

    Conclusions:

    • Eosinophils from HES patients demonstrate comparable in vitro phagocytic activity to normal eosinophils.
    • Ferritin uptake occurs via vacuolar pathways and does not affect eosinophil specific granules.
    • These findings contribute to understanding eosinophil function in HES.