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Annulate in four cases of diffuse lymphocytic lymphoma
Journal of the National Cancer Institute
|March 1, 1977
Summary
Annulate lamellae, abnormal nuclear membranes, and endoplasmic reticulum formations were found in diffuse lymphocytic lymphoma cases. These ultrastructural findings may offer new insights into lymphoma subtypes.
Area of Science:
- Cell Biology
- Oncology
- Pathology
Background:
- Diffuse lymphocytic lymphoma is a type of non-Hodgkin lymphoma.
- Ultrastructural abnormalities can provide insights into disease mechanisms and classification.
Purpose of the Study:
- To investigate the presence and characteristics of annulate lamellae in diffuse lymphocytic lymphoma.
- To identify associated cellular membrane abnormalities in these lymphoma cases.
Main Methods:
- Electron microscopy was used to examine lymphoma tissue samples.
- Morphological analysis focused on identifying annulate lamellae and other membrane structures.
Main Results:
- Annulate lamellae were observed in four cases of diffuse lymphocytic lymphoma.
- Two of these lymphomas were well-differentiated, and two were of intermediate differentiation.
- Associated membrane abnormalities included excessive nuclear membrane blebbing and lattice-like endoplasmic reticulum formations.
Conclusions:
- Annulate lamellae and specific membrane abnormalities are present in some diffuse lymphocytic lymphomas.
- These ultrastructural findings may serve as potential diagnostic or prognostic markers.
- Further research is warranted to understand the functional significance of these observations in lymphoma pathogenesis.