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Lack of indomethacin effect on thyroid function in man
The Journal of Clinical Endocrinology and Metabolism
|April 1, 1977
Summary
Indomethacin did not significantly alter thyroid hormone levels or TSH in euthyroid volunteers. Prostaglandins likely do not play a key role in regulating thyroid hormone secretion in humans.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Prostaglandins are implicated in various physiological processes.
- Their role in thyroid hormone regulation requires further investigation.
Purpose of the Study:
- To investigate the effect of indomethacin, a prostaglandin inhibitor, on thyroid hormone levels and TSH.
- To assess the physiological role of prostaglandins in thyroid hormone secretion.
Main Methods:
- Administration of indomethacin (200 mg daily for 2 days) to euthyroid volunteers.
- Measurement of serum triiodothyronine, thyroxine, and TSH.
- Evaluation of thyroidal iodine release (TIR) patterns.
- Prostaglandin A1 infusion in one subject.
Main Results:
- Indomethacin did not significantly affect serum triiodothyronine, thyroxine, or TSH levels.
- Minor, variable changes in TIR were observed in euthyroid subjects.
- No consistent alteration in TIR or TSH was noted with indomethacin or prostaglandin A1 infusion.
Conclusions:
- Prostaglandins likely do not have a significant physiological role in modulating TSH or thyroid hormone secretion in humans.
- Indomethacin does not appear to be a potent inhibitor of thyroid hormone regulation in this context.