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Related Experiment Videos

Edema associated with ibuprofen therapy.

R T Schooley, P F Wagley, P S Lietman

    JAMA
    |April 18, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Ibuprofen therapy can cause significant weight gain due to salt and water retention. Discontinuing the drug resolved the edema, highlighting a potential side effect of nonsteroidal anti-inflammatory drugs.

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    Area of Science:

    • Pharmacology
    • Clinical Medicine

    Background:

    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
    • Previous reports linked phenylbutazone and indomethacin to fluid retention.

    Observation:

    • A patient experienced a 15-kg weight gain within three weeks of starting ibuprofen.
    • The observed edema resolved after discontinuing ibuprofen therapy.

    Findings:

    • Ibuprofen is associated with salt and water retention.
    • This effect is similar to that seen with other NSAIDs like phenylbutazone and indomethacin.

    Implications:

    • Clinicians should monitor for fluid retention in patients on ibuprofen.
    • Awareness of this NSAID side effect is crucial for patient management and safety.