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Membrane alterations in hemolysis: Internalization of plasmalemma induced by primaquine
Science (New York, N.Y.)
|May 16, 1969
Abstract:
Incubation of normal human erythrocytes with primaquine, a derivative of 8-aminoquinoline, results in internalization of the cell membrane and the formation of intracellular vacuoles. These changes are similar to those observed in other types of cells in pinocytosis. The reduction in surface cell membrane which accompanies internalization of plasmalemma may be generally significant in the destruction of red cells.
Insights
Primaquine causes red blood cells (erythrocytes) to internalize their cell membrane, forming vacuoles. This process, similar to pinocytosis, may contribute to red blood cell destruction.
Area of Science:
- Hematology
- Cell Biology
- Pharmacology
Background:
- Primaquine is an 8-aminoquinoline derivative.
- Erythrocytes are normal human red blood cells.
- Cellular changes in erythrocytes can indicate potential destruction.
Purpose of the Study:
- To investigate the effects of primaquine on human erythrocytes.
- To characterize the morphological changes induced by primaquine in red blood cells.
- To explore the mechanism of primaquine-induced erythrocyte alterations.
Main Methods:
- Incubation of normal human erythrocytes with primaquine.
- Microscopic observation of cellular changes.
- Comparison with known cellular processes like pinocytosis.
Main Results:
- Primaquine induces internalization of the erythrocyte cell membrane.
- Intracellular vacuoles are formed within the erythrocytes.
- Observed changes resemble pinocytosis in other cell types.
Conclusions:
- Primaquine causes significant morphological alterations in human erythrocytes.
- The observed membrane internalization and vacuole formation may be a key factor in red blood cell destruction.
- These findings suggest a potential mechanism for primaquine's effects on red blood cells.