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Monozygotic twins with temporal arteritis and ophthalmic arteritis
Acta Ophthalmologica
|April 1, 1977
Summary
This case report details ophthalmic arteritis in identical twins, highlighting a rare improvement in vision with corticosteroid treatment. It suggests a potential genetic link and calls for further research into tissue type antigen associations.
Area of Science:
- Ophthalmology
- Genetics
- Rheumatology
Background:
- Temporal arteritis, a form of large vessel vasculitis, commonly affects individuals over 50.
- Ophthalmic involvement is a serious complication, potentially leading to irreversible vision loss.
Observation:
- A rare case of ophthalmic arteritis in monozygotic (identical) twins is presented.
- The twins presented with symptoms at ages 72 and 77.
- One twin experienced a notable improvement in severely reduced vision following corticosteroid therapy, a rare occurrence.
Findings:
- The case underscores the potential role of genetic factors in the predisposition to temporal arteritis.
- The study highlights the unusual positive response to corticosteroid treatment in one patient's vision.
Implications:
- Further investigation into the genetic underpinnings of temporal arteritis is warranted.
- Exploring potential associations between temporal arteritis and specific human leukocyte antigens (tissue type antigens) may offer new diagnostic or therapeutic insights.