Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dose finding in antibacterial chemotherapy (author's transl)].

K Metzger

    Arzneimittel-Forschung
    |February 1, 1977
    PubMed
    Summary

    This study explores bacterial infection treatment by examining the bacteria-man-chemical system. It discusses challenges in translating in vitro data to effective therapies and introduces a safety factor for drug dosing.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neck involvement and disease recurrence in adenoid cystic carcinoma of the minor salivary glands: the role of surgery in primary and progressive disease.

    International journal of oral and maxillofacial surgery·2020
    Same author

    ON THE DARKREACTIVATION MECHANISM IN ULTRAVIOLET IRRADIATED BACTERIA.

    Biochemical and biophysical research communications·2015
    Same author

    Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death.

    Cell death and differentiation·2015
    Same author

    DNA-Based Vaccination with Polycistronic Expression Plasmids.

    Methods in molecular medicine·2011
    Same author

    Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

    Journal of internal medicine·2010
    Same author

    Expression of putative sex-determining genes during the thermosensitive period of gonad development in the snapping turtle, Chelydra serpentina.

    Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2008

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Context:

    • Bacterial infections pose a significant global health challenge.
    • Effective antimicrobial therapy relies on understanding complex host-pathogen-drug interactions.
    • Translating in vitro antimicrobial data to clinical practice is often difficult.

    Purpose:

    • To analyze the interplay within the bacteria-man-chemical system for effective infection therapy.
    • To identify challenges in determining and applying in vitro antimicrobial values in clinical settings.
    • To discuss the fundamental principles of chemotherapy and necessary adjustments for practical application.

    Summary:

    • The study examines bacterial infection therapy within the context of the bacteria-man-chemical system.
    • It addresses experimental challenges in obtaining and applying in vitro antimicrobial data.
    • The basic equation of chemotherapy is discussed, alongside factors necessitating a safety margin in dose recommendations.

    Impact:

    • Provides insights into optimizing antimicrobial therapy strategies.
    • Highlights critical considerations for accurate drug dosing in clinical practice.
    • Contributes to a better understanding of chemotherapy principles for treating bacterial infections.

    Related Experiment Videos