Related Experiment Videos
Corneal ulcer caused by Pasteurella multocida
American Journal of Ophthalmology
|April 1, 1977
Abstract:
A 44-year-old woman with Graves' disease and exophthalmos developed a severe corneal ulcer caused by Pasteurella multocida after being bumped on her right eye by her pet dog. The organism was transferred from the patient to an abraded rabbit cornea and produced a similiar corneal ulcer and hypopyon.
Insights
A dog-related eye injury led to a severe corneal ulcer in a Graves' disease patient. Pasteurella multocida, transferred from the patient, caused a similar ulcer in a rabbit model, highlighting zoonotic potential.
Area of Science:
- Ophthalmology
- Microbiology
- Zoonotic Diseases
Background:
- Graves' disease and exophthalmos can increase ocular surface vulnerability.
- Ocular trauma, even minor, can predispose to microbial keratitis.
Observation:
- A 44-year-old woman with Graves' disease and exophthalmos sustained a corneal ulcer after ocular trauma from a pet dog.
- Pasteurella multocida was identified as the causative agent of the corneal ulcer.
Findings:
- Experimental transfer of Pasteurella multocida from the patient to an abraded rabbit cornea successfully replicated a similar corneal ulcer and hypopyon.
- This demonstrates the pathogenicity of Pasteurella multocida in corneal infections.
Implications:
- Highlights the risk of zoonotic transmission of ocular pathogens from pets to humans.
- Emphasizes the importance of considering animal contact in cases of severe microbial keratitis, especially in immunocompromised or predisposed individuals.
- Suggests Pasteurella multocida as a potential cause of severe keratitis following minor ocular trauma.