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[Toxicological study on piprozoline (author's transl)].

J Wiegleb, M Herrmann, F Leuschner

    Arzneimittel-Forschung
    |January 1, 1977
    PubMed
    Summary
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    Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (piprozoline) showed mild side effects like sedation in rats and vomiting in dogs during chronic toxicity studies. However, it did not cause birth defects or affect fertility in tested animals.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Drug Safety

    Context:

    • Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate, also known as piprozoline, is a compound investigated for its pharmacological properties.
    • Assessing the safety profile of new chemical entities is crucial before clinical application.

    Purpose:

    • To evaluate the chronic toxicity, reproductive toxicity, and teratogenicity of ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate.
    • To determine the safety of piprozoline in animal models under various administration routes and conditions.

    Summary:

    • Chronic oral administration of piprozoline in rats for 6 months resulted in slight sedation, decreased body weight gain, reduced food intake, and adrenal gland enlargement in the highest dosage group.
    • Intragastric administration in dogs for 6 months led to mild hyperemesis in the highest dosage group.

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  • Subtoxic doses of piprozoline administered to pregnant rats and rabbits did not induce fetal malformations.
  • Oral application of piprozoline did not affect the fertility or breeding capacity of rats.

    • Impact:

    • This study provides essential toxicological data on piprozoline, informing its potential therapeutic applications and guiding future safety assessments.
    • The findings suggest that piprozoline exhibits a generally favorable safety profile regarding reproductive and developmental toxicity at tested doses.