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[Therapy with coronary dilators].

W Schaper

    Arzneimittel-Forschung
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    The search for new antianginal therapies should not focus on specific coronary vasodilation. While some vasodilators show efficacy, their effects in humans differ from animal models, limiting current therapeutic concepts.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Context:

    • Antianginal therapy aims to alleviate chest pain associated with angina.
    • Vasodilating agents are commonly used in managing angina.
    • The pathophysiological basis of these therapies requires critical evaluation.

    Purpose:

    • To critically review the pathophysiological basis of antianginal therapy with vasodilating agents.
    • To assess the validity of pursuing specific coronary vasodilation for new antianginal agents.

    Summary:

    • Current antianginal therapies using vasodilating agents are reviewed.
    • Evidence suggests that the concept of specific coronary vasodilation may not be a fruitful avenue for developing new antianginal drugs.
    • Observed efficacy in clinical trials may not directly correlate with the proposed mechanism of coronary vasodilation due to differing effects in humans versus experimental animals.

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    Impact:

    • Findings challenge the prevailing concept of specific coronary vasodilation in antianginal drug development.
    • Highlights the importance of species-specific drug responses in pharmacological research.
    • Suggests a need for re-evaluation of therapeutic strategies for angina based on robust pathophysiological understanding.