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Related Experiment Videos

Visual abnormalities in a pregnancy following bromocriptin medication.

R S Corbey, J R Cruysberg, R Rolland

    Obstetrics and Gynecology
    |July 1, 1977
    PubMed
    Summary

    Hyperprolactinemia treatment with Bromocriptin restored ovarian function and led to a successful pregnancy. However, visual field defects developed during pregnancy, resolving after delivery.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Neuro-ophthalmology

    Background:

    • Hyperprolactinemia, a condition of elevated prolactin levels, can cause menstrual irregularities like amenorrhea.
    • An enlarged sella turcica may indicate a pituitary adenoma, a common cause of hyperprolactinemia.
    • Bromocriptine is a dopamine agonist used to treat hyperprolactinemia by suppressing prolactin secretion.

    Observation:

    • A patient with hyperprolactinemia, amenorrhea, and an enlarged sella turcica, despite lacking galactorrhea, was treated with Bromocriptine.
    • Ovarian function was restored, leading to a successful pregnancy.
    • Progressive visual field abnormalities emerged during the pregnancy.

    Findings:

    • The pregnancy was complicated by worsening visual field defects.

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  • Termination of pregnancy at 39 weeks was necessitated by the visual disturbances.
  • Postpartum, the visual field defects resolved, and visual acuity normalized within a week.

    • Implications:

    • This case highlights the importance of monitoring for visual changes in pregnant patients with hyperprolactinemia, particularly those with pituitary enlargement.
    • Management of hyperprolactinemia during pregnancy requires careful consideration of potential complications affecting both mother and fetus.
    • The reversibility of visual field defects after delivery suggests a dynamic relationship between hormonal changes, pituitary size, and optic nerve compression.