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Coagulation factors in chronic liver disease

G W Donaldson, S H Davies, A Darg

    Journal of Clinical Pathology
    |March 1, 1969
    PubMed

    Insights

    Chronic liver disease causes complex clotting defects involving multiple factors. Thrombotest effectively identifies factor IX deficiency, serving as a valuable liver function test.

    Area of Science:

    • Hematology
    • Hepatology
    • Clinical Chemistry

    Background:

    • Chronic liver disease (CLD) frequently leads to hemostatic abnormalities.
    • Coagulopathy in CLD can increase bleeding risk during procedures like surgery or biopsy.

    Purpose of the Study:

    • To investigate coagulation defects in patients with CLD.
    • To evaluate the utility of Thrombotest as a liver function test for detecting factor IX deficiency.

    Main Methods:

    • Coagulation studies were performed on 30 patients with CLD.
    • Assessed levels of coagulation factors V, VII, IX (Christmas factor), and prothrombin.
    • Utilized Thrombotest and one-stage prothrombin time assays.

    Main Results:

    • A complex clotting defect involving factors V, VII, IX, and prothrombin was observed.
    • Some patients exhibited factor IX depression despite a normal one-stage prothrombin time.
    • Thrombotest proved effective in identifying factor IX deficiency in this cohort.

    Conclusions:

    • Coagulation factor assessment is crucial for patients with CLD undergoing invasive procedures.
    • Thrombotest can serve as a useful additional liver function test for detecting factor IX deficiency.

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