Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatal poisoning with verapamil.

H P Gelbke, H J Schlicht, G Schmidt

    Archives of Toxicology
    |June 18, 1977
    PubMed
    Summary

    Fatal verapamil poisoning was analyzed using gas chromatography. High concentrations in organs and blood confirmed an extreme overdose, far exceeding therapeutic levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Isolation, crystallization, crystal structure analysis and refinement of B-phycoerythrin from the red alga Porphyridium sordidum at 2.2 A resolution.

    Journal of molecular biology·1992
    Same author

    [Knowledge of the Austrian pathologist Carl Sternberg (1872-1935). Attempt at a historical presentation of clinical information about lymphogranulomatosis].

    Der Pathologe·1992
    Same author

    [Traumatic aneurysm of the hand--a rare complication of a stab injury].

    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·1992
    Same author

    Is Escherichia coli invading tubuloepithelial cells?

    Zentralblatt fur Bakteriologie : international journal of medical microbiology·1992
    Same author

    Churg-Strauss syndrome, cardiac involvement and life threatening ventricular arrhythmias.

    Australian and New Zealand journal of medicine·1992
    Same author

    Does physical exercise influence bowel transit time in healthy young men?

    The American journal of gastroenterology·1992

    Area of Science:

    • Toxicology
    • Analytical Chemistry
    • Pharmacology

    Background:

    • Verapamil (Isoptin) is a calcium channel blocker used therapeutically.
    • Fatal poisonings require accurate toxicological analysis for confirmation.
    • Establishing lethal dose thresholds is crucial for forensic toxicology.

    Observation:

    • A case of fatal verapamil poisoning is presented.
    • Biological samples (liver, kidney, blood, urine, gastric contents) were analyzed.
    • Verapamil was isolated using protein precipitation and ion pair extraction.

    Findings:

    • Quantitative determination by gas chromatography with a nitrogen specific flame ionization detector.
    • Measured verapamil concentrations: liver 5500 ng/g, kidney 2000 ng/g, blood 590 ng/g, urine 250 ng/g, gastric contents 3 mg.
    • Blood concentration (590 ng/g) significantly exceeded therapeutic levels (11-65 ng/g).

    Implications:

    • The findings confirm an extreme verapamil overdose as the cause of death.
    • This case highlights the importance of sensitive analytical methods in forensic toxicology.
    • Understanding toxic levels aids in managing overdose cases and legal investigations.

    Related Experiment Videos