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[Pharmacological studies on the antiphlogistic effect of pentosanpolysulfate in combination with metamizol]
Abstract:
In the present study we investigated the antiinflammatory effect of pentosanpolysulfate (SP 54) in combination with metamizol using different forms of rat paw edema (induced by dextrane, hyaluronidase, trypsin, formaldehyde, carragenine or kaolin). After s. c. application Probaphen, a new drug containing pentosanpolysulfate, metamizol, and lidocaine, proved in our experiments to exert an antiphlogistic effect about 40% stronger than the equivalent amount of SP 54 alone. Since pentosanpolysulfate by itself has no analgetic activity, its combination with metamizol results in a formulation which is not only a more potent antiinflammatory drug but will aslo counteract pains which accompany most edematous reactions. Probaphen may therefore be suggested for the treatment of rheumatoid arthritis and similar inflammatory and edematous processes. First clinical studies and reports on Probaphen fully support our pharmacological results.
Insights
This study shows Probaphen, combining pentosanpolysulfate (SP 54) and metamizol, offers a potent anti-inflammatory and analgesic effect. This new drug formulation is effective for inflammatory and edematous conditions like rheumatoid arthritis.
Area of Science:
- Pharmacology
- Inflammation Research
Context:
- Investigated the anti-inflammatory effects of pentosanpolysulfate (SP 54) in combination with metamizol.
- Utilized various rat paw edema models (dextrane, hyaluronidase, trypsin, formaldehyde, carragenine, kaolin).
Purpose:
- To evaluate the combined anti-inflammatory efficacy of pentosanpolysulfate (SP 54) and metamizol.
- To assess the therapeutic potential of a new drug, Probaphen, containing SP 54, metamizol, and lidocaine.
Summary:
- Probaphen demonstrated a significantly stronger antiphlogistic effect compared to SP 54 alone.
- The combination of SP 54 with metamizol provides both anti-inflammatory and analgesic properties, addressing pain associated with edema.
- Pharmacological results were supported by initial clinical studies and reports on Probaphen.
Impact:
- Suggests Probaphen as a potential treatment for rheumatoid arthritis and other inflammatory/edematous conditions.
- Highlights the synergistic benefits of combining pentosanpolysulfate with metamizol for enhanced therapeutic outcomes.