Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinidine-induced agranulocytosis.

E V Eisner, R M Carr, A R MacKinney

    JAMA
    |August 22, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Quinidine sulfate therapy caused agranulocytosis and septicemia in a patient. An IgG antibody, specific to quinidine, was identified as the cause of these severe adverse drug reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dyadic interventions to promote physical activity and reduce sedentary behaviour: systematic review and meta-analysis.

    Health psychology review·2018
    Same author

    Health risks in wastewater irrigation: comparing estimates from quantitative microbial risk analyses and epidemiological studies.

    Journal of water and health·2007
    Same author

    Guidelines for the safe use of wastewater in agriculture: revisiting WHO guidelines.

    Water science and technology : a journal of the International Association on Water Pollution Research·2004
    Same author

    Meeting the challenge of tobacco use within the Medicaid population.

    WMJ : official publication of the State Medical Society of Wisconsin·2001
    Same author

    Simultaneous determination of zidovudine and lamivudine in human serum using HPLC with tandem mass spectrometry.

    Journal of pharmaceutical and biomedical analysis·2000
    Same author

    Browpexy: lateral orbicularis muscle fixation as an adjunct to upper blepharoplasty.

    Plastic and reconstructive surgery·1997

    Area of Science:

    • Hematology
    • Immunology
    • Pharmacology

    Background:

    • Adverse drug reactions can manifest with severe hematological complications.
    • Drug-induced agranulocytosis is a rare but life-threatening condition.

    Observation:

    • A 75-year-old male developed agranulocytosis and septicemia after eight weeks of quinidine sulfate treatment.
    • The patient presented with symptoms indicative of a severe systemic infection and a critical drop in white blood cell count.

    Findings:

    • An immunoglobulin G (IgG) antibody was detected in the patient's serum.
    • This antibody demonstrated quinidine-dependent reactivity in complement-dependent leukocytotoxicity and leukoagglutination assays.
    • The antibody was specific to quinidine and did not cross-react with quinine, confirming drug specificity.

    Related Experiment Videos

    Implications:

    • This case highlights a specific mechanism of quinidine-induced agranulocytosis mediated by drug-dependent antibodies.
    • Understanding such immune mechanisms is crucial for diagnosing and managing adverse drug reactions.
    • Further research into drug-antibody interactions can improve patient safety and therapeutic strategies.