Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cigarette-smoking effect on platelet function.

G Grignani, G Gamba, E Ascari

    Thrombosis and Haemostasis
    |June 30, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Advanced breast-cancer - a randomized study of different doses of epirubicin associated with fixed doses of cyclophosphamide and 5-Fluorouracil.

    Oncology reports·2011
    Same author

    The use of peripheral-blood hematopoietic progenitors mobilized with standard-dose chemotherapy plus granulocyte-colony-stimulating factor to support multicyclic dose-intensive chemotherapy for advanced breast-cancer.

    Oncology reports·2011
    Same author

    A prospective, controlled, nonrandomized study on prophylactic parenteral dichloromethylene bisphosphonate (clodronate) in multiple-myeloma.

    International journal of oncology·2011
    Same author

    Sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following intensified, accelerated CEE (cyclophosphamide, epirubicin, etoposide) chemotherapy in patients with solid tumors.

    International journal of oncology·2011
    Same author

    Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry.

    Annals of oncology : official journal of the European Society for Medical Oncology·2004
    Same author

    Response to first-line chemotherapy and long-term survival in patients with multiple myeloma: results of the MM87 prospective randomised protocol.

    European journal of cancer (Oxford, England : 1990)·2002
    Same journal

    Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

    Thrombosis and haemostasis·2026
    Same journal

    The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

    Thrombosis and haemostasis·2026
    Same journal

    Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

    Thrombosis and haemostasis·2026
    Same journal

    Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

    Thrombosis and haemostasis·2026
    Same journal

    Methylglyoxal Promotes RBC-Driven Procoagulant Activity and Venous Thrombosis under Diabetes-Relevant Conditions.

    Thrombosis and haemostasis·2026
    Same journal

    Management of Inferior Vena Cava Thrombosis: Guidance from the Italian Society for the Study of Haemostasis and Thrombosis.

    Thrombosis and haemostasis·2026
    See all related articles

    Cigarette smoking significantly increases platelet aggregation and adhesiveness in young heavy smokers. Older individuals, with or without cerebrovascular disease, showed no significant increase in platelet activity after smoking.

    Area of Science:

    • Cardiovascular Science
    • Hematology
    • Public Health

    Background:

    • Cigarette smoking is a major risk factor for cardiovascular diseases.
    • Platelet activation plays a crucial role in thrombotic events.
    • The immediate effects of smoking on platelet function may differ by age.

    Purpose of the Study:

    • To investigate the acute impact of cigarette smoking on platelet aggregation and adhesiveness.
    • To compare the effects in young heavy smokers, older normal subjects, and older patients with cerebrovascular disease.

    Main Methods:

    • Recruitment of three groups: young heavy smokers (20-40 yrs), older normal subjects (43-72 yrs), and older patients with cerebrovascular disease (45-75 yrs).
    • All subjects were heavy smokers ( >20 cigarettes/day).

    Related Experiment Videos

  • Measurement of ADP-induced platelet aggregation and platelet adhesiveness before and after smoking 2 cigarettes.

    • Main Results:

    • Young heavy smokers exhibited a significant increase in ADP-induced platelet aggregation and adhesiveness post-smoking.
    • Older subjects (normal and with cerebrovascular disease) did not show a significant change in platelet activity after smoking.
    • Suggests age-related differences in the immediate thrombotic response to smoking.

    Conclusions:

    • Young heavy smokers demonstrate heightened platelet reactivity to acute cigarette exposure.
    • Platelet response to smoking appears diminished in older individuals, irrespective of cerebrovascular disease status.
    • Further research is warranted to elucidate the mechanisms behind age-dependent platelet sensitivity to smoking.