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Related Experiment Videos

Marathon run II: Effects on platelet aggregation.

C Dimitriadou, A Dessypris, C Louizou

    Thrombosis and Haemostasis
    |June 30, 1977
    PubMed
    Summary
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    Marathon running significantly increases platelet count and aggregation sensitivity in trained athletes. This hyperaggregability suggests a need for pre-race hemostatic balance evaluation.

    Area of Science:

    • Exercise Physiology
    • Hematology

    Background:

    • Marathon running is a strenuous endurance event.
    • Understanding physiological responses to prolonged exercise is crucial for athlete health.

    Purpose of the Study:

    • To investigate the effects of marathon running on platelet count and aggregation in trained amateur runners.
    • To assess platelet sensitivity to aggregating agents post-exercise.

    Main Methods:

    • Blood samples were collected from 10 trained amateur runners (9 aged 34-48, 1 aged 65) before and after a 42.2 km marathon.
    • Platelet count and in vitro platelet aggregation (induced by ADP and collagen) were measured.

    Main Results:

    • A statistically significant increase in mean platelet count was observed post-marathon (p < 0.001).

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  • Platelets exhibited significantly heightened sensitivity to both ADP and collagen-induced aggregation (p < 0.001).
  • Both the intensity and velocity of platelet aggregation increased significantly.

    • Conclusions:

    • Prolonged strenuous exercise, such as marathon running, leads to platelet hyperaggregability even in trained individuals.
    • A comprehensive medical examination of hemostatic balance is recommended prior to marathon participation.