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Disodium cromoglycate in the prevention of induced asthma
British Medical Journal
|April 26, 1969
Abstract:
In 13 patients with allergic asthma disodium cromoglycate protected fully only two from an allergen-induced asthmatic attack.Inhalation of disodium cromoglycate did not improve lung function in five patients with long-standing chronic asthma.Previous clinical trials do not show convincing evidence that this drug improves bronchial asthma in a high percentage of cases, but it seems to help a small minority of patients.
Insights
Disodium cromoglycate offered limited protection against allergen-induced asthma attacks in most patients. This asthma medication showed minimal benefit for chronic asthma, suggesting it helps only a small patient group.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Allergic asthma is a chronic inflammatory airway disease.
- Disodium cromoglycate is an inhaled mast cell stabilizer.
- Its efficacy in managing asthma symptoms is debated.
Purpose of the Study:
- To evaluate the effectiveness of disodium cromoglycate in allergic asthma.
- To assess its impact on lung function in chronic asthma patients.
Main Methods:
- Administered disodium cromoglycate to patients with allergic asthma.
- Assessed protection against allergen-induced asthmatic attacks.
- Measured lung function in patients with long-standing chronic asthma.
Main Results:
- Only 2 out of 13 patients with allergic asthma were fully protected.
- Disodium cromoglycate did not improve lung function in 5 chronic asthma patients.
- Clinical trials show inconsistent evidence of broad efficacy.
Conclusions:
- Disodium cromoglycate demonstrates limited effectiveness in a majority of asthma patients.
- The drug may benefit a small subset of individuals with asthma.
- Further research is needed to identify patient subgroups who respond to this treatment.