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Decrease of non-suppressible insulin-like activity after pancreatectomy and normalization by insulin therapy.

J E Eigenmann, M Becker, B Kammermann

    Acta Endocrinologica
    |August 1, 1977
    PubMed
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    Pancreatectomy drastically reduced non-suppressible insulin-like activity (NSILA-S) in dogs. Insulin therapy restored NSILA-S levels, indicating insulin controls its synthesis and secretion.

    Area of Science:

    • Endocrinology
    • Metabolic Research

    Background:

    • Non-suppressible insulin-like activity (NSILA-S) plays a role in glucose metabolism.
    • The pancreas's role in NSILA-S regulation was previously unclear.

    Purpose of the Study:

    • To investigate the relationship between the pancreas, insulin, and NSILA-S levels.
    • To determine the impact of pancreatectomy and insulin therapy on NSILA-S.

    Main Methods:

    • Serum NSILA-S was measured in dogs before and after pancreatectomy.
    • Samples were analyzed using Sephadex G-50 chromatography.
    • Growth hormone levels were monitored during severe diabetes.

    Main Results:

    • Pancreatectomy led to a significant decrease in NSILA-S levels.

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  • Insulin therapy gradually normalized NSILA-S levels.
  • Elevated growth hormone concentrations were observed during the diabetic phase.

    • Conclusions:

    • The pancreas is not the primary site for NSILA-S synthesis or release.
    • NSILA-S levels are not always correlated with growth hormone levels.
    • Insulin significantly influences the synthesis and secretion of NSILA-S.