[A mathematical model for the description of oxygen-diffusion in the intervillous space of the human placenta...

The oxygen consumption has a central place in the complicated interaction between diminished oxygen supply and degenerative trophoblastic tissue change. In the present investigation, that serves as a mathematical model, the problem of the diffusion equation for the constant state is discussed and solved. It is shown that the diminishing of length of the radius of the maternal blood compartment has the same meaning as the decrease in the flow velocity. The influence of the mass transfer coefficient h on the oxygen partial pressure and on the oxygen transfer is investigated. The influence of parameter variations on the placental alterations during toxemia is discussed and their clinical importance is obvious. Our theoretical model elusidates the value of an early therapeutical approach in the case of toxemia.