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Megavitamins for minimal brain dysfunction. A potentially dangerous therapy.

B A Shaywitz, N J Siegel, H A Pearson

    JAMA
    |October 17, 1977
    PubMed
    Summary

    Vitamin A intoxication can occur from megavitamin therapy for minimal brain dysfunction. An abnormal bone scan was an early indicator of this condition in a young boy.

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    Area of Science:

    • Pediatric Medicine
    • Toxicology
    • Nutritional Science

    Background:

    • Megavitamin therapy, involving high doses of vitamins, is sometimes used for conditions like minimal brain dysfunction.
    • Vitamin A, while essential, can be toxic in excessive amounts.

    Observation:

    • A 4-year-old boy undergoing megavitamin therapy for minimal brain dysfunction presented with symptoms suggestive of vitamin A intoxication.
    • Diagnostic imaging, specifically a bone scan, revealed abnormalities.

    Findings:

    • The patient's condition was directly linked to excessive Vitamin A intake from the prescribed therapy.
    • The abnormal bone scan served as a crucial early diagnostic clue, preceding other definitive findings.

    Implications:

    • Highlights the potential dangers of unsupervised megavitamin therapy in children.
    • Underscores the importance of considering iatrogenic causes, like vitamin toxicity, in pediatric diagnoses.
    • Suggests that bone scans may be a valuable tool for early detection of vitamin A intoxication.

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