Ca2+-transport inhibition by the antitumor agents adriamycin and daunomycin

The antitumor agents adriamycin and daunomycin inhibit Ca2+-transport in mitochondria from Ehrlich ascites carcinoma cells as well as in a biphasic model system. The experimental results indicate that both antibiotics interact with phospholipids. The significance of these observations in the pharmacological behavior of these anticancer compounds is discussed.