Familial lupus erythematosus

Related Experiment Video

Updated: Jul 28, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

D Brustein, J M Rodriguez, W Minkin

    JAMA
    |November 21, 1977
    PubMed

    Insights

    Neonatal lupus erythematosus can manifest with discoid lupus erythematosus (DLE) lesions in infants born to mothers with DLE. These skin lesions may persist and new ones may develop in affected children.

    Area of Science:

    • Pediatric Dermatology
    • Rheumatology
    • Immunodermatology

    Background:

    • Discoid lupus erythematosus (DLE) is a chronic autoimmune skin condition.
    • Maternal autoimmune diseases can sometimes affect newborns.

    Observation:

    • A 28-month-old child developed DLE lesions at 2 months of age, with persistent and evolving lesions.
    • An 11-month-old infant presented with a probable lupus erythematosus rash at 1 week of age.

    Findings:

    • The cases suggest the possibility of DLE developing in infants of mothers with DLE.
    • Early onset of cutaneous lupus manifestations in neonates is observed.

    Implications:

    • Highlights the importance of monitoring infants born to mothers with DLE for cutaneous manifestations.
    • Suggests a potential transplacental transfer of autoantibodies or other factors contributing to neonatal lupus.

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