[A study of two non-complementary H-2 mutations in mice using skin transplantation and serologic analysis]

Hz1 and M505 are two mutants affected the Kend of H-2 major histocompatibility system in mouse. Inability of M505 to complement Hz1 is considered as an evidence that the same gene is altered by both mutations. The gained antigens of two mutants can cross-react in vivo, and the lost antigenic determinants are not identical as revealed in skin grafting tests with presensitized recipients. The antiserum ASY-0,15, (d X a) anti-i, could differentiate between normal and mutant cells as well as between both mutants in absorption tests. These results show that some haptenic determinants are changed in the Hz1 and M505 mutations together with changes of histocompatibility determinants.