[A new model for demonstrating the hepatic first-pass effect (author's transl)].

Area of Science:

• Veterinary Surgery
• Vascular Access
• Animal Models

Context:

• Chronic vascular access is crucial for repeated physiological measurements in animal research.
• Previous methods may have limitations in long-term patency and repeated experimental use.
• Developing reliable chronic catheterization techniques is essential for advancing preclinical studies.

Purpose:

• To describe a reproducible surgical procedure for chronic implantation of vascular catheters.
• To evaluate the long-term patency of implanted catheters in major abdominal vessels.
• To establish a model for serial physiological monitoring in canine subjects.

Summary:

• A surgical technique for implanting vascular catheters into the hepatic vein, aorta, and portal vein of dogs is presented.
• Daily flushing of the implanted catheters was performed to maintain patency.
• Catheter patency was successfully maintained for months, enabling multiple experimental trials.

Impact:

• This procedure provides a reliable method for chronic vascular access in canine research.
• Facilitates longitudinal studies and repeated measurements in preclinical cardiovascular and hepatic research.
• Enhances the utility of dogs as experimental models for investigating complex physiological processes.