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Physico-chemical and analytical studies on Halopredone acetate
Arzneimittel-Forschung
|January 1, 1977
Summary
This study details the physico-chemical and analytical properties of halopredone acetate, a synthetic corticosteroid. Analytical methods were developed for its characterization, purity assessment, and stability testing.
Area of Science:
- Pharmaceutical Chemistry
- Analytical Chemistry
Background:
- Halopredone acetate is a synthetic corticosteroid with potential therapeutic applications.
- Comprehensive characterization is essential for drug development and quality control.
Purpose of the Study:
- To report the physico-chemical and spectroscopic properties of halopredone acetate.
- To describe densitometric and high-pressure liquid chromatographic (HPLC) quantitative analytical methods.
- To provide purity tests, identify potential impurities, and conduct stability assessments.
Main Methods:
- Spectroscopic techniques including UV, CD, ORD, IR, 1H-NMR, 19F-NMR, 13C-NMR, and MS were employed.
- Chromatographic methods such as Thin-Layer Chromatography (TLC) and HPLC were utilized.
- Densitometry was used for quantitative analysis.
Main Results:
- Detailed physico-chemical and spectroscopic data for halopredone acetate were obtained.
- Validated analytical methods for quantitative determination and purity assessment were established.
- Information on potential synthesis-related impurities and stability profiles was generated.
Conclusions:
- The reported data provide a comprehensive analytical profile of halopredone acetate.
- The developed methods are suitable for quality control and stability studies of halopredone acetate.
- This characterization supports the further development and regulatory evaluation of halopredone acetate.