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Chemical modification of crude timothy grass pollen extract. I. Antigenicity and immunogenicity changes following
International Archives of Allergy and Applied Immunology
|January 1, 1976
Abstract:
Glutaraldehyde modification was found to reduce the allergenic potency of crude timothy pollen extracts yet even highly substituted materials retained the capability of inducing the formation of allergen-specific antibody in animals. Experiments showed that these antibodies were capable of blocking skin test reactions to native timothy allergens in pollen-sensitive human volunteers. The value of glutaraldehyde-modified allergen extracts for use in desensitization vaccine therapy is discussed.