[Pharmacokinetics of multilayer vincamine dragees. Study of normal subjects]

The study deals with the bioavailability of a newly developed vincamine multi-layer dragee (Pervincamin forte retard) which showed an extremely continuous release of the active principle in vitro. Furthermore the correlation between half-life and age of the volunteers was to be established. The investigations were performed on six volunteers. After GC analysis of the vincamine-serum concentration the following pharmacokinetic profile could be established: The substance appears in the streaming blood with an invasion half-life of 53 min. The maximum is reached after 3 h. After oral application of 16 mg the concentration will amount to 36 ng/ml. The apparent elimination half-life caused by the sustained release from of the multi-layer dragee was 9.13 h. 24 h after application there was still a mean serum concentration of 5.74 ng/ml to be detected. Between age of the subjects and serum half-life is a marked linear correlation.