Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiologic mechanisms of hydrocephalus.

M P Berger, R A Brumback

    The Journal of Clinical Psychiatry
    |February 1, 1978
    PubMed
    Summary

    Hydrocephalus is a neurological condition caused by an imbalance of forces at the interface between brain ventricles and surrounding tissue. This imbalance can lead to progressive enlargement of the ventricles and worsening neurological symptoms. The condition may worsen either due to ongoing force imbalances or due to damage from reduced blood flow near the ventricles. Treatment should aim to correct the specific cause of the imbalance, such as removing a blockage in cerebrospinal fluid flow or addressing abnormal pulse waves from blood vessels. When the cause cannot be directly treated, the focus should be on reducing the force inside the ventricles, increasing the inward force on the brain, and improving blood flow to damaged tissue. The study emphasizes the importance of tailoring treatment to the specific underlying mechanism rather than just managing symptoms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On Covariance Adjustment In The Analysis Of Time-Structured Data.

    Multivariate behavioral research·2016
    Same author

    Empirical Comparison Between Factor Analysis and Multidimensional Item Response Models.

    Multivariate behavioral research·2016
    Same author

    Adult-onset xeroderma pigmentosum neurological disease--observations in an autopsy case.

    Clinical neuropathology·2002
    Same author

    Authorship designation and the Journal of Child Neurology in 2002.

    Journal of child neurology·2002
    Same author

    Local influence to detect influential data structures for generalized linear mixed models.

    Biometrics·2002
    Same author

    Dementia: the University of Oklahoma autopsy experience.

    The Journal of the Oklahoma State Medical Association·2001

    Area of Science:

    • Neurological disorders
    • Cerebrospinal fluid dynamics
    • Neurocritical care

    Background:

    Hydrocephalus remains a complex neurological condition with unclear pathophysiological mechanisms. Prior research has shown that ventricular enlargement can occur due to imbalances in cerebral forces. However, the specific interplay between cerebrospinal fluid (CSF) flow and periventricular tissue injury is not fully understood. Established knowledge includes the role of CSF obstruction in obstructive hydrocephalus. Yet, the mechanisms behind progressive hydrocephalus are less defined. This gap motivated researchers to explore the forces at the ventricular-cerebral interface. No prior work had resolved how ischemic injury contributes to disease progression. Understanding these mechanisms could improve diagnostic and therapeutic approaches. This paper's contribution lies in synthesizing the force dynamics and ischemic factors involved.

    Purpose Of The Study:

    The study aimed to clarify the pathophysiologic mechanisms underlying hydrocephalus. It focused on the forces at the ventricular-cerebral interface and their impact on disease progression. The specific problem addressed is the lack of consensus on how force imbalances and ischemia contribute to hydrocephalus. The motivation stems from the need to guide treatment decisions based on underlying mechanisms. The authors sought to distinguish between obstructive and progressive forms of the disease. They also aimed to identify therapeutic targets beyond simple CSF diversion. The study sought to integrate clinical observations with biomechanical principles. This approach could lead to more effective treatment strategies.

    Keywords:
    hydrocephalus treatmentventricular force imbalancecerebrospinal fluid dynamicsneurological disorders

    Frequently Asked Questions

    The authors suggest that hydrocephalus may progress due to continued force imbalance or periventricular ischemic injury.

    The study proposes reducing intraventricular force, augmenting inward brain force, and improving periventricular tissue oxygenation.

    The authors propose that correcting the specific abnormal force vector, such as increased pulse waves from an ectatic basilar artery, can be more effective than general interventions.

    The study suggests that periventricular ischemic injury may contribute to progressive hydrocephalus when force imbalances persist.

    Related Experiment Videos

    Main Methods:

    The researchers reviewed existing literature on hydrocephalus pathophysiology. They analyzed the forces at the ventricular-cerebral interface and their effects. The approach included examining how CSF flow obstruction and pulse waves influence disease progression. They also considered the role of periventricular ischemia in disease development. The study synthesized findings from clinical and experimental studies. The authors evaluated how force imbalances contribute to ventricular enlargement. They considered both mechanical and ischemic factors in their analysis. This review approach allowed them to identify key mechanisms and therapeutic implications.

    Main Results:

    The strongest finding is that hydrocephalus arises from a disequilibrium of forces at the ventricular-cerebral interface. Progressive disease may result from continued force imbalance or ischemic injury. The study identified three therapeutic targets: reducing intraventricular force, augmenting inward brain force, and improving periventricular tissue oxygenation. It also highlighted the importance of addressing the specific abnormal force vector. For example, shunting can correct increased pulse waves from an ectatic basilar artery. The findings suggest that treatment should be tailored to the underlying mechanism. The study found that ischemic injury contributes to disease progression in some cases. These results provide a framework for targeted therapeutic interventions.

    Conclusions:

    The authors concluded that hydrocephalus results from force imbalances at the ventricular-cerebral interface. They emphasized the need to address the specific abnormal force vector when possible. The study suggests that treatment should target the underlying mechanism rather than just symptoms. The authors propose that reducing intraventricular force is a key therapeutic strategy. They also suggest augmenting inward brain force as a complementary approach. The study highlights the importance of improving periventricular tissue oxygenation. These conclusions are based on the synthesis of existing evidence. The authors did not claim that these mechanisms are essential but suggested they are important.

    The authors propose that shunting can be used to correct increased intraventricular pulse waves caused by an ectatic basilar artery.

    The authors suggest that treatment should be guided by the underlying mechanism rather than just symptoms.