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Hoffman's syndrome: a peculiar case.

C Bartoloni, N Gentiloni, G Ghirlanda

    The Journal of Clinical Psychiatry
    |February 1, 1978
    PubMed
    Summary
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    Adult-onset myxedema can cause painful muscle cramps and elevated muscle enzymes. Early patient observation may prevent detectable muscle damage in this condition.

    Area of Science:

    • Endocrinology
    • Neurology
    • Muscle Physiology

    Background:

    • Adult-onset myxedema is a condition of hypothyroidism affecting adults.
    • Muscular symptoms are not commonly associated with myxedema.
    • Elevated muscle enzymes can indicate muscle damage.

    Observation:

    • A 50-year-old woman presented with severe muscle cramps and high muscle enzyme levels.
    • The patient's symptoms were attributed to adult-onset myxedema.
    • Muscle biopsies showed no histological or ultrastructural abnormalities.

    Findings:

    • Adult-onset myxedema can manifest with significant muscular symptoms, including cramps and elevated creatine kinase.
    • The absence of muscle pathology suggests that myxedema-induced muscle dysfunction may be reversible or functional rather than structural.

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  • Early diagnosis and treatment are crucial.

    • Implications:

    • This case highlights the importance of considering endocrine disorders, such as myxedema, in the differential diagnosis of unexplained muscle symptoms.
    • It suggests that prompt management of myxedema may prevent permanent muscle damage.
    • Further research is needed to understand the mechanisms of myxedema-related myopathy.