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Amniotic fluid proteins and lipids in normal and high-risk pregnancies and their relation to foetal outcome

A Youssef, R Sakr, M F El-Hawary

    The Gazette of the Egyptian Paediatric Association
    |January 1, 1977
    PubMed

    Insights

    Amniotic fluid lipid phosphorus and phospholipids were lower in high-risk pregnancies, especially with adverse outcomes. Levels increased in toxaemic mothers with healthy newborns.

    Area of Science:

    • Obstetrics and Gynecology
    • Neonatal Health
    • Biochemistry

    Background:

    • Amniotic fluid composition provides insights into fetal well-being.
    • Lipid profiles in amniotic fluid may indicate pregnancy complications.

    Purpose of the Study:

    • To analyze amniotic fluid lipid profiles in high-risk pregnancies.
    • To compare these findings with normal pregnancies and correlate with pregnancy outcomes.

    Main Methods:

    • Quantification of amniotic fluid total lipids, lipid phosphorus, phospholipids, total cholesterol, total proteins, and inorganic phosphorus.
    • Comparison between high-risk (diabetic, toxaemic) and normal pregnancies.
    • Correlation with pregnancy outcomes including stillbirths, RDS, and intrapartum death.

    Main Results:

    • Significantly decreased amniotic fluid total lipids, lipid phosphorus, phospholipids, and total cholesterol in diabetic and toxaemic pregnancies.
    • More pronounced decreases in lipid phosphorus and phospholipids in cases with stillbirths, neonatal respiratory distress syndrome (RDS), or intrapartum death.
    • Increased lipid phosphorus and phospholipids in toxaemic mothers delivering healthy neonates, despite elevated total cholesterol.

    Conclusions:

    • Amniotic fluid lipid composition is altered in high-risk pregnancies, reflecting fetal distress.
    • Specific lipid changes, particularly in phospholipids, may serve as indicators of adverse pregnancy outcomes.
    • Further research into amniotic fluid lipidomics could enhance prenatal diagnostics.

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