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[A multiple iteration program for determining global pharmacokinetic constants on a digital computer (author's

Arzneimittel-Forschung

|January 1, 1978

Summary

This program simplifies pharmacokinetic analysis by calculating key constants and the Bateman function using graphical data. It offers a reliable tool for kineticists in daily practice.

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Area of Science:

Pharmacokinetics
Computational Biology
Drug Development

Context:

Accurate determination of pharmacokinetic parameters is crucial for drug efficacy and safety.
Traditional methods for calculating pharmacokinetic constants can be time-consuming and complex.
There is a need for efficient and reliable tools to support pharmacokinetic analysis.

Purpose:

To introduce a user-friendly program for calculating essential pharmacokinetic constants.
To automate the determination of parameters like tmax, cmax, and kel.
To enable calculation of the Bateman function for drug concentration over time.

Summary:

The program utilizes graphical data to obtain initial pharmacokinetic values (tmax, cmax, kel).
It performs multiple iterations to calculate all critical pharmacokinetic constants.

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The Bateman function is calculated for the 0-24 hour period, tailored to specific problems.

Impact:

Enhances the efficiency and reliability of pharmacokinetic analysis in daily laboratory work.
Provides a valuable tool for researchers and scientists involved in drug kinetics.
Facilitates a deeper understanding of drug behavior within the body through accurate constant determination.