Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human lingual tuberculosis. An ultrastructural study.

R L Miller, D J Krutchkoff, B S Giammara

    Archives of Pathology & Laboratory Medicine
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Barium ion sensing with IPG K<sup>+</sup> molecular probes.

    The Analyst·2025
    Same author

    Fluorescence imaging of individual ions and molecules in pressurized noble gases for barium tagging in <sup>136</sup>Xe.

    Nature communications·2024
    Same author

    Demonstration of event position reconstruction based on diffusion in the NEXT-white detector.

    The European physical journal. C, Particles and fields·2024
    Same author

    Mechanism of internal fertilization in Pegea socia (Tunicata, Thaliacea), a salp with a solid oviduct.

    Journal of morphology·2018
    Same author

    Effects of Coralliophila violacea on tissue loss in the scleractinian corals Porites spp. depend on host response.

    Diseases of aquatic organisms·2016
    Same author

    A retrospective review of treatment and response of high-risk mast cell tumours in dogs.

    Veterinary and comparative oncology·2014

    Human oral tuberculosis granulomas feature monocytes, epithelioid cells, and multinucleated giant cells. These cells, including macrophages, play key roles in the inflammatory response within granulomas.

    Area of Science:

    • Immunology
    • Cell Biology
    • Pathology

    Background:

    • Tuberculosis (TB) is a significant global health challenge.
    • Oral manifestations of TB, though less common, can occur.
    • Understanding the cellular composition of oral TB lesions is crucial for diagnosis and treatment.

    Observation:

    • Human oral tuberculosis granulomas are characterized by specific cell types.
    • Predominant cells identified include monocytes, epithelioid cells, and multinucleated giant cells.
    • The distinct morphology of these cells suggests specialized functions within the granuloma.

    Findings:

    • Monocytes differentiate into macrophages and epithelioid cells in vivo.
    • Multinucleated giant cells are believed to form from the fusion of macrophages.

    Related Experiment Videos

  • These phagocytic cells, along with other inflammatory cells, are integral to granulomatous inflammation in oral TB.

    • Implications:

    • Elucidating cell differentiation pathways in oral TB granulomas can inform therapeutic strategies.
    • Recognizing these cellular components aids in the pathological diagnosis of oral tuberculosis.
    • Further research into the functional roles of these cells may reveal novel therapeutic targets.