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Endomyocardial fibrosis with calcification of the myocardium
Archives of Pathology & Laboratory Medicine
|August 1, 1978
Insights
Endomyocardial fibrosis with intramyocardial calcification mimicked constrictive pericarditis. Pathological findings confirmed Davies' disease, a condition originally described in Uganda.
Area of Science:
- Cardiology
- Pathology
Background:
- Endomyocardial fibrosis (EMF) is a rare infiltrative disease of the myocardium.
- Intramyocardial calcification is an uncommon finding in EMF.
- Restrictive cardiomyopathy presents with impaired diastolic filling of the ventricles.
Observation:
- A case presented with symptoms of restrictive cardiomyopathy.
- Clinical presentation mimicked constrictive pericarditis.
- Imaging and clinical data suggested an infiltrative cardiac process.
Findings:
- Pathological examination revealed endomyocardial fibrosis with extensive intramyocardial calcification.
- The findings were consistent with classical Davies' disease.
- Davies' disease is characterized by fibrosis and calcification of the endocardium and subendocardium.
Implications:
- This case highlights the importance of considering EMF in the differential diagnosis of restrictive cardiomyopathy.
- Recognition of Davies' disease is crucial for appropriate patient management.
- Understanding the pathological features of EMF aids in differentiating it from other cardiomyopathies.
Abstract:
A case of endomyocardial fibrosis with intramyocardial calcification was characterized by symptoms of restrictive cardiomyopathy resembling constrictive pericarditis. Pathological findings were typical of those found in classical Davies' disease, originally encountered and described in Uganda.