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Persistent creatine kinase MB isoenzyme without cardiac disease
Archives of Pathology & Laboratory Medicine
|September 1, 1978
Abstract:
Although the creatine kinase MB isoenzyme may be useful in the diagnosis of myocardial injury, it is also found in the sera of patients with a number of noncardiac diseases. It may also occur in apparently normal individuals, as described in this case report. Hence, the diagnosis of myocardial injury should never be based solely on the presence of creatine kinase MB isoenzyme in the serum, but should be supported by additional clinical and laboratory data.
Insights
Creatine kinase MB isoenzyme aids myocardial injury diagnosis but can appear in non-cardiac diseases or normal individuals. Diagnosis requires additional clinical and laboratory data, not just this enzyme.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Cardiology
Background:
- The creatine kinase MB isoenzyme (CK-MB) is a biomarker often used in diagnosing myocardial injury.
- Elevated CK-MB levels typically indicate damage to heart muscle tissue.
Observation:
- This case report details the presence of CK-MB in apparently normal individuals.
- CK-MB was also observed in patients with various non-cardiac diseases.
Findings:
- The study highlights that CK-MB is not exclusively indicative of myocardial injury.
- Non-specific elevations of CK-MB can occur in conditions unrelated to the heart.
Implications:
- Diagnosis of myocardial injury should not rely solely on CK-MB serum levels.
- Confirmatory clinical and laboratory data are essential for accurate diagnosis of heart damage.