Influences on the absorption of diphenylhydantoin preparations

The absorption of different preparations of diphenylhydantoin was studied in 9 healthy persons under different conditions. With both galenic preparations of two different factories (diphenylhydantoin-acid) the absorption was significant by less in the fasting state than after breakfast. Whereas the absorption was almost identical for both preparations in the fasting state, it differed significantly after ingestion of a breakfast: the one preparation, DPH-A, was less well absorbed than the other, DPH-B (7,9 mcg/ml serumconcentration 5 hours after oral administration of 5 mg/kg DPH-B versus 5,7 mcg/ml serumconcentration 5 hours after administration of 5 mg/kg DPH-A).